Product Name	ZRANB2
Chinese Name	Zinc finger proteinZNF265抗体
Alias	ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; OTTHUMP00000011240; OTTHUMP00000011241; ZRAB2_HUMAN; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing; ZIS; ZIS1; ZIS2; ZNF265.
Research Area	Cell biology  transcriptional regulatory factor  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZRANB2: 101-200/330
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR. Function: ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection. Subunit: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1. Subcellular Location: Nuclear Post-translational modifications: Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the ZRANB2 family. Contains 2 RanBP2-type zinc fingers. SWISS: O95218 Gene ID: 9406 Database links: Entrez Gene: 9406 Human Entrez Gene: 53861 Mouse Entrez Gene: 58821 Rat Omim: 604347 Human SwissProt: O95218 Human SwissProt: Q9R020 Mouse SwissProt: O35986 Rat Unigene: 194718 Human

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