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Product Name ZRANB2/ZNF265 Chinese Name Zinc finger protein265抗体 Alias ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; ZSC23_HUMAN OTTHUMP00000011240; OTTHUMP00000011241; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing; ZIS; ZIS1; ZIS2; ZNF265. Research Area immunology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ZRANB2/ZNF265: 251-330/330 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
Function:
ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection.
Subunit:
Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
Subcellular Location:
Nuclear
Post-translational modifications:
Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the ZRANB2 family.
Contains 2 RanBP2-type zinc fingers.
SWISS:
O95218
Gene ID:
9406
Database links:Entrez Gene: 9406 Human
Entrez Gene: 53861 Mouse
Omim: 604347 Human
SwissProt: O95218 Human
SwissProt: Q9R020 Mouse
Unigene: 194718 Human
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