Product Name	GRPEL2
Chinese Name	GRPEL2蛋白抗体
Alias	GrpE like 2, mitochondrial; GrpE protein homolog 2; GRPE2_HUMAN; GRPEL 2; Grpel2; mitochondrial; Mt GrpE#2; Mt-GrpE#2.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GRPEL2: 33-130/225
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GrpEL2 (GrpE protein homolog 2) is a 225 amino acid mitochondrial matrix protein and component of the PAM complex. Consisting of Tim44, Tim14, HSP 70, Magmas, GrpEL1 and GrpEL2, the PAM complex plays an essential role in the ATP-dependent translocation of transit peptide-containing proteins to the mitochondrial matrix from the inner membrane. GrpEL2 regulates the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins and stimulates its ATPase activity. The gene encoding GrpEL2 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70. Subcellular Location: Mitochondrion matrix. Similarity: Belongs to the grpE family. SWISS: Q8TAA5 Gene ID: 134266 Database links: Entrez Gene: 134266 Human Entrez Gene: 17714 Mouse Entrez Gene: 688777 Rat SwissProt: Q8TAA5 Human SwissProt: O88396 Mouse Unigene: 511816 Human Unigene: 269657 Mouse Unigene: 103300 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GRPEL2) Polyclonal Antibody, Unconjugated (SL16325R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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