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Product Name FP100 Chinese Name FP100蛋白抗体 Alias C17orf70; chromosome 17 open reading frame 70; ; Faap100; Fanconi anemia associated protein 100 kDa subunit; Fanconi anemia associated protein 100kDa; Fanconi anemia core complex 100 kDa subunit; Fanconi anemia-associated protein of 100 kDa; FP100_HUMAN. Research Area Cell biology immunology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 93kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FP100: 421-520/881 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]
Function:
Play a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitylation and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.
Subcellular Location:
Nucleus.
SWISS:
Q0VG06
Gene ID:
80233
Database links:Entrez Gene: 80233 Human
Omim: 611301 Human
SwissProt: Q0VG06 Human
Unigene: 313905 Human
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