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Product Name FOXJ2 Chinese Name FOXJ2蛋白抗体 Alias FHX; Fork head homologous X; Forkhead box J2; Forkhead box protein J2; FOXJ2; FOXJ2_HUMAN. Research Area Cell biology immunology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FOXJ2: 111-210/574 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FOXJ2, Forkhead box protein J2, is a 574 amino acid protein encoded by the human gene FOXJ2. FOXJ2 is a novel forkhead factor, belonging to the forkhead family, with a dual DNA binding specificity. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. forkhead factors are known to play important roles both during development and in adults. In the testis, FOXJ2 is expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, only Sertoli cells of the testis showed expression of FOXJ2. In the ovary, only granulosa cells of the follicles express the factor. Neither mature spermatozoa nor oocytes have been found to express FOXJ2. However, both the trophectoderm (TE) and the inner cell mass (ICM) cell layers of the blastocyst express FOXJ2.
Function:
Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 fork-head DNA-binding domain.
SWISS:
Q9P0K8
Gene ID:
55810
Database links:Entrez Gene: 55810 Human
Entrez Gene: 60611 Mouse
SwissProt: Q9P0K8 Human
SwissProt: Q9ES18 Mouse
Unigene: 120844 Human
Unigene: 87142 Mouse
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