Product Name	Cathepsin D
Chinese Name	组织蛋白酶D轻链抗体
Alias	Cathepsin D light chain; CatD; CathepsinD; Cathepsin-D; CLN10; CPSD; CTSD; Lysosomal aspartyl peptidase; MGC2311; CATD_HUMAN.
literatures	Specific References  (3)     |     SL1615R has been referenced in 3 publications. [IF=3.51] Hossain, Shahdat, Hiroyuki Arai, and Osamu Shido. "Neuroprotective Effect of Madecassoside Evaluated Using Amyloid β1-42-Mediated in Vitro and in Vivo Alzheimer’s Disease Models." International Journal of Indigenous Medicinal Plants (2014).  ELISA ;  Rat.   PubMed:notpostedyet [IF=2.74] Bailey Balouch. et al. Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death. Plos One. 2021 Feb;16(2):e0239689  ICC ;  Human.   PubMed:33561134 [IF=1.71] Liao, Peng, et al. "Organellar proteome analyses of ricin toxin-treated HeLa cells." Toxicology and industrial health (2014): 0748233714549066.  WB ;  Human.   PubMed:25227225
Research Area	Cell biology  immunology  Neurobiology  Synthesis and Degradation  Cell adhesion molecule  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	11/38/45kDa
Cellular localization	cytoplasmic Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cathepsin D light chain: 101-200/412
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease. Function: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Subcellular Location: Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Tissue Specificity: Expressed in the aorta extrcellular space (at protein level). Post-translational modifications: N- and O-glycosylated. DISEASE: Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10); also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. Similarity: Belongs to the peptidase A1 family. SWISS: P07339 Gene ID: 1509 Database links: Entrez Gene: 1509 Human Entrez Gene: 13033 Mouse Omim: 116840 Human SwissProt: P07339 Human SwissProt: P18242 Mouse Unigene: 654447 Human Unigene: 231395 Mouse
Product Picture	Sample: Lane 1: Rat Liver tissue lysates Lane 2: Rat Small intestine tissue lysates Primary: Anti-Cathepsin D (SL1615R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 11/38/45 kDa Observed band size: 46 kDa

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