Product Name	FOXA3
Chinese Name	肝The nucleus因子3抗体
Alias	FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; Foxa3; FOXA3_HUMAN; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3; hepatocyte nuclear factor 3 gamma; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; HNF3B; HNF3G; TCF-3G; TCF3G; Transcription factor 3G.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FOXA3: 51-150/350
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008] Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Subcellular Location: Nucleus. Tissue Specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: P55318 Gene ID: 3171 Database links: Entrez Gene: 3171 Human Entrez Gene: 503622 Cow Entrez Gene: 15377 Mouse Entrez Gene: 25100 Rat Omim: 602295 Human SwissProt: Q3Y598 Cow SwissProt: P55318 Human SwissProt: P35584 Mouse SwissProt: P32183 Rat Unigene: 36137 Human Unigene: 42260 Mouse Unigene: 10949 Rat
Product Picture	Sample: Hepg2(Human) Cell Lysate at 30 ug Primary: Anti-FOXA3 (SL16159R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kD Observed band size: 37 kD

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