Product Name	Focadhesin
Chinese Name	Focadhesin蛋白抗体
Alias	FOCAD; FOCAD_HUMAN; Focadhesin; KIAA1797.
literatures	Specific References  (1)     |     SL16158R has been referenced in 1 publications. [IF=4.799] Ruifang Sun. et al. FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells. PROG BIOPHYS MOL BIO. 2022 Jul;:  WB, IHC ;  Human.   PubMed:35788362
Research Area	Cell biology  immunology  Developmental biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	200kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Focadhesin: 1-100/1801
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The KIAA1797 gene product has been provisionally designated KIAA1797 pending further characterization. Function: Potential tumor suppressor in gliomas. Subunit: Interacts with VCL. Subcellular Location: Membrane. Cell junction; focal adhesion. Colocalizes with VCL in astrocytes. Tissue Specificity: Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines. SWISS: Q5VW36 Gene ID: 54914 Database links: Entrez Gene: 54914 Human SwissProt: Q5VW36 Human Unigene: 136247 Human

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