Product Name	FMO1
Chinese Name	肝黄素单加氧酶1抗体
Alias	Dimethylaniline monooxygenase [N oxide forming] 1; Dimethylaniline monooxygenase [N-oxide-forming] 1; Dimethylaniline oxidase 1; Fetal hepatic flavin containing monooxygenase 1; Fetal hepatic flavin-containing monooxygenase 1; Flavin containing monooxygenase 1 (fetal liver); Flavin Containing Monooxygenase 1; FMO 1; FMO1; FMO1_HUMAN; OTTHUMP00000033536; OTTHUMP00000033537.
Research Area	Tumour  Cell biology  immunology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FMO1: 301-400/532
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Subcellular Location: Microsome membrane. Endoplasmic reticulum membrane. Tissue Specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine. Similarity: Belongs to the FMO family. SWISS: Q01740 Gene ID: 2326 Database links: Entrez Gene: 2326 Human Entrez Gene: 14261 Mouse Entrez Gene: 25256 Rat Omim: 136130 Human SwissProt: Q01740 Human SwissProt: P50285 Mouse SwissProt: P36365 Rat Unigene: 1424 Human Unigene: 976 Mouse Unigene: 867 Rat

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