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Rabbit Anti-FMNL2 antibody
Rabbit Anti-FMNL2 antibody
FHOD2; FHOD1_HUMAN;Formin homology 2 domain containing protein 2; Formin like protein 2; KIAA1902.
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  • NO.:SL16150R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Monkey,)
    Applications:IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name FMNL2
Chinese Name FMNL2蛋白抗体
Alias FHOD2; FHOD1_HUMAN; Formin homology 2 domain containing protein 2; Formin like protein 2; KIAA1902.  
Research Area Cell biology  Signal transduction  G protein signal  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Monkey, )
Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 123kDa
Cellular localization cytoplasmic 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human FMNL2: 951-1050/1164 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

Function:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.

Subunit:
Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.

Tissue Specificity:
Ubiquitous. Highly expressed in spleen.

Post-translational modifications:
Phosphorylated by ROCK1.

Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

SWISS:
Q96PY5

Gene ID:
114793

Database links:

Entrez Gene: 114793 Human

Entrez Gene: 71409 Mouse

Entrez Gene: 311033 Rat

SwissProt: Q96PY5 Human

SwissProt: A2APV2 Mouse

Unigene: 654630 Human



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