Product Name	FGD2
Chinese Name	FGD2蛋白抗体
Alias	Fgd2; FGD2_HUMAN; FYVE; RhoGEF and PH domain-containing protein 2; ZFYVE4; Zinc finger FYVE domain-containing protein 4.
Research Area	Cell biology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FGD2: 501-600/655
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Fgd1 gene mutations result in faciogenital dysplasia (FGDY, Aarskog syndrome),an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures (1). FGD1 maps to human chromosome Xp11.21 and shares a high degree of sequence identity with the FGD2 (6p21.2) and the FGD3 (9q22) proteins (1-4). FGD1 encodes a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42 (1,5). FGD2 is present in several diverse tissues during embryogenesis, suggesting a role in embryonic development (2). FGD3 stimulates fibroblasts to form filopodia, which are actin microspikes formed upon the stimulation of Cdc42 (1). All FGD family members contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins (2). These proteins control essential signals required during embryonic development (6,7). Function: Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection > ruffle membrane. Recruitement to the endosome and ruffle membrane requires the presence of phosphoinositides. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. SWISS: Q7Z6J4 Gene ID: 221472 Database links: Entrez Gene: 221472 Human Omim: 605091 Human SwissProt: Q7Z6J4 Human Unigene: 509664 Human

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