Product Name	ABCB5
Chinese Name	ATPBinding protein家族5抗体
Alias	ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.
literatures	Specific References  (6)     |     SL1604R has been referenced in 6 publications. [IF=6.022] Julia Riedl. et al. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. 2021 Mar 01  WB ;  Mouse.   PubMed:33609408 [IF=5.923] Anna Kusienicka. et al. Heme Oxygenase-1 Has a Greater Effect on Melanoma Stem Cell Properties Than the Expression of Melanoma-Initiating Cell Markers. Int J Mol Sci. 2022 Jan;23(7):3596  FC ;  Mouse.   PubMed:35408953 [IF=4.77] Kaushik, Gaurav, et al. "Honokiol inhibits melanoma stem cells by targeting notch signaling." Molecular carcinogenesis (2014).  WB ;  Human.   PubMed:25491779 [IF=0] Hardt, Olaf, et al. "SSEA4 AND ST3GAL2 AS CHEMOTHERAPEUTIC DRUG RESPONSE BIOMARKERS." U.S. Patent No. 20,150,316,556. 5 Nov. 2015.  FCM ;  Mouse.   PubMed:US Patent No20150335744 [IF=] Nandabalan K. NOVEL IMMUNOMODULATORY THERAPEUTIC STRATEGIES TARGETING TUMORS IN CANCER. US 2018 / 0134771 A1  ABCB5 inhibitor ;   PubMed:US2018/0134771A1 [IF=] Nandabalan K et al. NOVEL IMMUNOMODULATORY THERAPEUTIC STRATEGIES TARGETING TUMORS IN CANCER. US Patent App. 15/572,422, 2018  Other ;  Human.   PubMed:US20180134771A1
Research Area	Tumour  Signal transduction  Channel protein  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	89/138kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABCB5: 841-883/1257 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008] Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues. Similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 2 ABC transporter domains. SWISS: Q2M3G0 Gene ID: 340273 Database links: Entrez Gene: 340273 Human Omim: 611785 Human SwissProt: Q2M3G0 Human Unigene: 404102 Human
Product Picture	Sample: Lane 1: Mouse B16 cell lysates Lane 2: Mouse Testis tissue lysates Primary: Anti-ABCB5 (SL1604R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 89/138 kD Observed band size: 125 kD

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