Product Name	CK20
Chinese Name	细胞角蛋白20抗体
Alias	Cytokeratin 20; CK 20; CK20; Cytokeratin20; K20; Keratin 20; Keratin type I cytoskeletal 20; Keratin20; KRT 20; KRT 21; KRT20; KRT21; MGC35423; Protein IT; K1C20_HUMAN.
literatures	Specific References  (5)     |     SL1588R has been referenced in 5 publications. [IF=7.419] Amira Abugomaa. et al. Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues. BIOMED PHARMACOTHER. 2022 Oct;154:113597  IHC ;  Mouse.   PubMed:36030590 [IF=5.923] Mohamed Elbadawy. et al. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Jan;22(19):10763  IHC ;  Bat.   PubMed:34639103 [IF=4.136] Yasushi Nakai. et al. 5‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis. ONCOL REP. 2022 Oct;48(4):1-13  IHC ;  Mouse.   PubMed:36082808 [IF=3.998] Amira Abugomaa et al. Establishment of 2.5 D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports | (2020) 10:9393.  ICF ;  Dog.   PubMed:doi:10.1038/s41598-020-66229-w [IF=3.998] Abugomaa A et al. Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Sci Rep. 2020 Jun 10;10(1):9393.  ICF ;  Dog.   PubMed:32523078
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CK20: 151-250/424
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cytokeratin 20 is a type I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system and is present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack cytokeratin 20. Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). Subunit: Heterotetramer of two type I and two type II keratins. Associates with KRT8. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. Post-translational modifications: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. Similarity: Belongs to the intermediate filament family. SWISS: P35900 Gene ID: 54474 Database links: Entrez Gene: 54474 Human Entrez Gene: 66809 Mouse Entrez Gene: 286912 Rat Omim: 608218 Human SwissProt: P35900 Human SwissProt: Q9D312 Mouse SwissProt: P25030 Rat Unigene: 84905 Human Unigene: 28042 Mouse Unigene: 9887 Rat 结构蛋白（Structural Proteins） CK-20细胞角蛋白-20主要用于Tumour方面的研究，近年来大多用于消化系统恶性Tumour的鉴别，主要在胞浆。
Product Picture	Sample: Large intestine (Mouse) Lysate at 40 ug Primary: Anti-CK20 (SL1588R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD

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