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Product Name KLF13 Chinese Name 肠道内富含的Kruppel样因子13kt Alias Basic transcription element binding protein 3; BTE binding protein 3; BTEB3; C2 H2 zinc finger protein; FKLF 2; FKLF2; Kruppel like factor 13; Novel Sp1 like zinc finger transcription factor; NSLP1; RANTES factor of late activated T lymphocytes 1; RFLAT-1; RFLAT 1; RFLAT1; Transcription factor NSLP1; KLF13_HUMAN. Research Area Cell biology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KLF13: 197-249/288 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Kruppel-like factor 13 (KLF13) belongs to a family of transcription factors that contain three classical zinc finger DNA binding domains consisting of a zinc atom tetrahedrally coordinated by two cysteines and two histidines (C2H2 motif). These transcription factors bind to GC rich sequences and related GT and CACCC boxes. KLF13 appears to be an important component of the transcription network required for heart development and cholesterol homeostasis.
Function:
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
Q9Y2Y9
Gene ID:
51621
Database links:Entrez Gene: 51621 Human
Entrez Gene: 50794 Mouse
Omim: 605328 Human
SwissProt: Q9Y2Y9 Human
SwissProt: Q9JJZ6 Mouse
Unigene: 525752 Human
Unigene: 240473 Mouse
Product Picture Tissue/cell: mouse intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-KLF13 Polyclonal Antibody, Unconjugated(SL1577R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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