Product Name	RAMP1
Chinese Name	受体活性修饰蛋白1抗体
Alias	calcitonin receptor like receptor activity modifying protein 1; RAMP 1; RAMP-1; CRLR activity modifying protein 1; receptor (G protein coupled) activity modifying protein 1; receptor activity modifying protein 1; Receptor activity modifying protein 1; RAMP1_HUMAN.
literatures	Specific References  (2)     |     SL1567R has been referenced in 2 publications. [IF=2.605] Pauza AG et al. Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease. (2018) Autonomic Neuroscience.Sep 18. pii: S1566-0702(18)30176-0  IF ;  Human.   PubMed:30274796 [IF=1.86] Qiao, Xi, et al. "Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction."Nephrology (2015).  WB ;  Rat.   PubMed:26014968
Research Area	The cell membrane受体  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RAMP1: 118-148/148 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the RAMP family of single transmembrane domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin receptor like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Subunit: Heterodimer of CALCRL and RAMP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. Similarity: Belongs to the RAMP family. SWISS: Q9WTJ5 Gene ID: 10267 Database links: Entrez Gene: 10267 Human Entrez Gene: 51801 Mouse Entrez Gene: 58965 Rat Omim: 605153 Human SwissProt: O60894 Human SwissProt: Q9WTJ5 Mouse SwissProt: Q9JJ74 Rat Unigene: 471783 Human Unigene: 3272 Mouse Unigene: 12265 Rat
Product Picture	Sample: Lane 1: Recombinant human RAMP1 protein(SL41350P) Primary: Anti-RAMP1 (SL1567R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: / kDa Observed band size: 32 kDa This image was generously provided by Xi Qiao from the Second Hospital of Shanxi Medical University. Formaldehyde fixed and paraffin embedded rat kidneys labeled with Rabbit Anti-RAMP1 Polyclonal Antibody (SL1567R) and followed by conjugation to a secondary antibody and counterstained with hematoxylin. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-RAMP1 Polyclonal Antibody, Unconjugated(SL1567R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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