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Rabbit Anti-EVPLL antibody
Rabbit Anti-EVPLL antibody
Envoplakin like; Envoplakin-like protein; EVPLL; EVPLL_HUMAN;
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Details

Product Name EVPLL
Chinese Name EVPLL蛋白抗体
Alias Envoplakin like; Envoplakin-like protein; EVPLL; EVPLL_HUMAN;  
Research Area Tumour  Cell biology  immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, 
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 34kDa
Cellular localization cytoplasmic The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human EVPLL: 101-200/301 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail EVPLL (envoplakin-like protein) is a 301 amino acid protein that belongs to the plakin or cytolinker family. The gene encoding EVPLL maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Similarity:
Belongs to the plakin or cytolinker family.

SWISS:
A8MZ36

Gene ID:
645027

Database links:

Entrez Gene: 645027 Human

SwissProt: A8MZ36 Human

Unigene: 462400 Human



Product Picture
Paraformaldehyde-fixed, paraffin embedded (Human stomach carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EVPLL) Polyclonal Antibody, Unconjugated (SL14651R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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