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Product Name DOPEY1 Chinese Name 迟钝蛋白家族1抗体 Alias Dopey-1; DOP1; DOP1_HUMAN; Dopey family member 1; DOPEY1; KIAA1117; Protein dopey 1; Protein dopey-1. Research Area Neurobiology Signal transduction Transporter Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 277kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DOPEY1: 351-450/2465 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Dopey-1 is a 2,465 amino acid protein that is thought to be involved in protein trafficking between the late golgi and early endosomes and may be involved in neurological alternations and mental retardation associated with Down syndrome. The gene encoding Dopey-1 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Function:
May be involved in protein traffic between late Golgi and early endosomes.
Similarity:
Belongs to the dopey family.
SWISS:
Q5JWR5
Gene ID:
23033
Database links:Entrez Gene: 23033 Human
Entrez Gene: 320615 Mouse
SwissProt: Q5JWR5 Human
SwissProt: Q8BL99 Mouse
Unigene: 520246 Human
Unigene: 708998 Human
Unigene: 245500 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DOPEY1) Polyclonal Antibody, Unconjugated (SL14409R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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