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Product Name INTS7/C1orf73 Chinese Name 1号染色体开放阅读框73抗体 Alias INTS7; 5930412E23Rik; DKFZP434B168; C1orf73; Chromosome 1 open reading frame 73; chunp6916; DKFZp434B168; FLJ10736; FLJ12447; Int7; INT7_HUMAN; integrator complex subunit 7; INTS7; Ints7 integrator complex subunit 7; OTTHUMP00000035211; RGD1308014. Research Area Cell biology immunology transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 107kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human INTS7/C1orf73: 30-130/962 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.
Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.
Subcellular Location:
Nucleus. Chromosome. Localizes to sites of DNA damage in a H2AX-independent manner.
Similarity:
Belongs to the Integrator subunit 7 family.
SWISS:
Q9NVH2
Gene ID:
25896
Database links:Entrez Gene: 25896 Human
Entrez Gene: 421374 Chicken
Omim: 611350 Human
SwissProt: Q5ZL91 Chicken
SwissProt: Q9NVH2 Human
Unigene: 369285 Human
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