Product Name	DEFB109
Chinese Name	防御素β-109/β-defensin 109抗体
Alias	Beta defensin 109; DB109_HUMAN; DEFB109 Beta defensin 109; Defensin beta 109.
Research Area	Cell biology  Developmental biology  Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	7.4kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEFB109: 23-87/87
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 109 is an 87 amino acid secreted protein that is notably expressed on the ocular surface and is found in reduced levels in microbial infection, therefore suggesting that this particular Beta-defensin is unlikely to have a major antimicrobial effect. Function: DEFB109 belongs to the beta defensin family. It has antibacterial activity. Subcellular Location: Secreted Similarity: Belongs to the beta-defensin family. SWISS: Q30KR1 Gene ID: 641517 Database links: Entrez Gene: 100286963 Human Entrez Gene: 641517 Human SwissProt: Q30KR1 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human stomach cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DEFB109) Polyclonal Antibody, Unconjugated (SL14243R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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