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Rabbit Anti-DECR2 antibody
Rabbit Anti-DECR2 antibody
2 4 dienoyl CoA reductase 2; 2 4 dienoyl CoA reductase 2 peroxisomal; 2; 4-dienoyl-CoA reductase 2; 4-dienoyl-CoA reductase; DECR 2; Decr2; DECR2_HUMAN; EC 1.3.1.34; pDCR; Peroxisomal 2 4 dienoyl CoA reductase; Peroxisomal 2; SDR17C1; Short chain dehydrog
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  • NO.:SL14240R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Horse,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name DECR2
Chinese Name 过氧化物酶体2抗体
Alias 2 4 dienoyl CoA reductase 2; 2 4 dienoyl CoA reductase 2 peroxisomal; 2; 4-dienoyl-CoA reductase 2; 4-dienoyl-CoA reductase; DECR 2; Decr2; DECR2_HUMAN; EC 1.3.1.34; pDCR; Peroxisomal 2 4 dienoyl CoA reductase; Peroxisomal 2; SDR17C1; Short chain dehydrogenase/reductase family 17C member 1.  
Research Area Cell biology  Cell type markers  The new supersedes the old  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Horse, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 31kDa
Cellular localization cytoplasmic 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human DECR2: 201-292/292 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail DECR2 is a 292 amino acid member of the short-chain dehydrogenases/reductases (SDR) protein family and the 2,4-dienoyl-CoA reductase protein subfamily. Localized to the peroxisome, DECR2 is an auxiliary enzyme of beta-oxidation that catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. DECR2 has also been shown to have catalytic activity towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA and short and medium chain 2,4-dienoyl-CoAs, suggesting that DECR2 is not a rate limiting step in the degradation of docosahexaenoic acid in the peroxisome. DECR2 is expressed as three isoforms produced by alternative splicing events.

Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Subunit:
Monomer, dimer and oligomer.

Subcellular Location:
Peroxisome.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

SWISS:
Q9NUI1

Gene ID:
26063

Database links:

Entrez Gene: 26063 Human

Entrez Gene: 26378 Mouse

Entrez Gene: 64461 Rat

SwissProt: Q9NUI1 Human

SwissProt: Q9WV68 Mouse

SwissProt: Q9Z2M4 Rat

Unigene: 628831 Human

Unigene: 655999 Human

Unigene: 292869 Mouse

Unigene: 144598 Rat



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