Product Name	CHES1
Chinese Name	CHES1蛋白抗体
Alias	C14orf116; Checkpoint suppressor 1; Forkhead box protein N3; Foxn3; FOXN3_HUMAN; FXN3; FXN3; PRO1635.
Research Area	Cell biology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CHES1: 401-490/490
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] Function: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). Subcellular Location: Nucleus. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: O00409 Gene ID: 1112 Database links: Entrez Gene: 1112 Human Entrez Gene: 71375 Mouse Entrez Gene: 314374 Rat Omim: 602628 Human SwissProt: O00409 Human SwissProt: Q499D0 Mouse Unigene: 434286 Human Unigene: 621371 Human Unigene: 341972 Mouse Unigene: 392143 Mouse Unigene: 448530 Mouse

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