Product Name	CELF3
Chinese Name	CELF3蛋白抗体
Alias	Bruno-like protein 1; BRUNOL1; CAG repeat protein 4; CAGH4; CELF-3; CELF3; CELF3_HUMAN; CUG-BP- and ETR-3-like factor 3; CUGBP Elav-like family member 3; ELAV-type RNA-binding protein 1; ERDA4; ETR-1; Expanded repeat domain protein CAG/CTG 4; RNA-binding protein BRUNOL-1; TNRC4; Trinucleotide repeat-containing gene 4 protein.
literatures	Specific References  (2)     |     SL13830R has been referenced in 2 publications. [IF=2.08] Xianmin Meng. et al. MicroRNA-34a and microRNA-146a target CELF3 and suppress the osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch. J Dent Sci. 2021 Dec;:  WB ;  Human.   PubMed:10.1016/j.jds.2021.11.011 [IF=0] Ma P et al. Mass spectrometric analysis of active ingredients in fertilized egg for lipid metabolism. 29 January 2020, PREPRINT (Version 1) available at Research Square.  WB ;  chicken.   PubMed:doi:10.21203/rs.2.22228/v1
Research Area	Cardiovascular  Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CELF3: 401-465/465
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010] Function: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in brain. Similarity: Belongs to the CELF/BRUNOL family. Contains 3 RRM (RNA recognition motif) domains. SWISS: Q5SZQ8 Gene ID: 11189 Database links: Entrez Gene: 11189 Human Omim: 612678 Human SwissProt: Q5SZQ8 Human Unigene: 26047 Human
Product Picture	Sample: Lovo (human)cell Lysate at 40 ug Primary: Anti- CELF3(SL13830R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52kD Observed band size: 57kD Sample: HepG2 (human)cell Lysate at 40 ug A549 (human)cell Lysate at 40 ug Primary: Anti- CELF3(SL13830R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52kD Observed band size: 57kD Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Cerebellum tissue lysates Lane 3: Rat Cerebrum tissue lysates Lane 4: Rat Cerebellum tissue lysates Lane 5: Human SH-SY5Y cell lysates Primary: Anti-CELF3 (SL13830R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 42-55 kD

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