Product Name	CEACAM7
Chinese Name	癌胚抗原相关Cell adhesion molecule7抗体
Alias	Carcinoembryonic antigen CGM 2; Carcinoembryonic antigen CGM2; Carcinoembryonic antigen gene family member 2; Carcinoembryonic antigen related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; CEACAM 7; CEACAM7; CEAM7_HUMAN; CGM 2; CGM2.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	26kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CEACAM7: 161-265/265
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEA family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. CEACAM7, also referred to as CEA gene-family member 2 (CGM2), is a member of the CEA family that is expressed in normal colorectal epithelia but is downregulated in colorectal cancers, suggesting that it may play a role in tumorigenesis. CECAM7 is expressed on the apical surface of highly differentiated epithelial cells in the colorectal mucosa as well as on isolated ductal epithelial cells within the pancreas. CECAM7 may play an important role in epithelial-microbial interactions. CD66a, a biliary glycoprotein, interacts with CEACAM7. Subcellular Location: Cell membrane. Tissue Specificity: Strongly down-regulated in colonic adenocarcinomas. Similarity: Belongs to the immunoglobulin superfamily. CEA family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q14002 Gene ID: 1087 Database links: Entrez Gene: 1087 Human SwissProt: Q14002 Human Unigene: 74466 Human

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