Product Name	SHROOM1
Chinese Name	SHROOM1蛋白抗体
Alias	Apical protein 2; APXL2; Protein Shroom1; SHRM1_HUMAN; Shroom family member 1; Shroom1.
literatures	Specific References  (1)     |     SL13735R has been referenced in 1 publications. [IF=4.556] Zhihua Zhao. et al. Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair. Int J Mol Sci. 2020 Jan;21(16):5821  WB ;  Human.   PubMed:32823670
Research Area	Tumour  Cell biology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SHROOM1: 121-220/852
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SHROOM1 is an 852 amino acid protein that contains one ASD1 domain and one ASD2 domain. Localized to both the cytoplasm and the cytoskeleton, SHROOM1 interacts with Actin and is thought to be involved in microtubule assembly during cell elongation, possibly playing a role in the development of the nervous system. Multiple isoforms of SHROOM1 exist due to alternative splicing events. The gene encoding SHROOM1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Function: May be involved in the assembly of microtubule arrays during cell elongation. Subcellular Location: Cytoplasm; cytoskeleton. Similarity: Belongs to the shroom family. Contains 1 ASD1 domain. Contains 1 ASD2 domain. SWISS: Q2M3G4 Gene ID: 134549 Database links: Entrez Gene: 134549 Human Entrez Gene: 71774 Mouse Entrez Gene: 287285 Rat Omim: 611179 Human SwissProt: Q2M3G4 Human SwissProt: Q5SX79 Mouse Unigene: 519574 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human colon cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Claudin) Polyclonal Antibody, Unconjugated (SL13753R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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