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Product Name PRELP Chinese Name PRELP蛋白抗体 Alias 55 kDa leucine rich repeat protein of articular cartilage; MST161; MSTP161; Prelp; PRELP_HUMAN; Prolargin; Prolargin proteoglycan; Proline arginine rich end leucine rich repeat protein; Proline-arginine-rich end leucine-rich repeat protein; Proline/arginine rich end leucine rich repeat protein; SLRR2A. literatures Specific References (1) | SL13707R has been referenced in 1 publications.[IF=6.208] Andressa V. B. Nogueira. et al. Obesity Modifies the Proteomic Profile of the Periodontal Ligament. INT J MOL SCI. 2023 Jan;24(2):1003 IHC ; Rat.Research Area Cell biology Signal transduction Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 42kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PRELP: 151-250/382 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PRELP (proline/arginine-rich end leucine-rich repeat protein), also known as Prolargin, MST161, SLRR2A or MSTP161, is a 382 amino acid secreted protein that localizes to the extracellular matrix. Belonging to the Class II subfamily of the small leucine-rich proteoglycan (SLRP) family, PRELP contains twelve LRR (leucine-rich) repeats, which are motifs consisting of 20-29 residues that are present in numerous proteins with diverse functions and provide versatile structural framework for the formation of protein-protein interactions. Highly expressed in cartilage, basement membranes and developing bone, PRELP is considered a glycosaminoglycan (GAG)- and collagen-binding anchor protein that associates with the basement membrane heparan sulfate proteoglycan perlecan. PRELP acts as a linker between the extracellular matrix and the cell surface of proteoglycans and may be partially responsible for Hutchinson-Gilford progeria (HGP), an extremely rare genetic disorder that causes premature, rapid aging shortly after birth.
Function:
May anchor basement membranes to the underlying connective tissue.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.
Tissue Specificity:
Connective tissue.
Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Contains 12 LRR (leucine-rich) repeats.
SWISS:
P51888
Gene ID:
5549
Database links:Entrez Gene: 5549 Human
Omim: 601914 Human
SwissProt: P51888 Human
Unigene: 632481 Human
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