Product Name	AHNAK
Chinese Name	神经Cell differentiation相关蛋白AHNAK抗体
Alias	AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227.
Research Area	Cardiovascular  Neurobiology  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	629kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human AHNAK: 1351-1450/5890
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function. Function: May be required for neuronal cell differentiation. Subunit: Interacts with DYSF; the interaction is direct and Ca(2+)-independent. Subcellular Location: Nucleus. Similarity: Contains 1 PDZ (DHR) domain. SWISS: Q09666 Gene ID: 79026 Database links: Entrez Gene: 79026 Human Entrez Gene: 66395 Mouse Entrez Gene: 191572 Rat Entrez Gene: 718802 Rhesus monkey Omim: 103390 Human SwissProt: Q09666 Human Unigene: 502756 Human

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