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Product Name GNG11 Chinese Name G蛋白γ11/Gγ11 抗体 Alias G protein gamma 11 subunit; GBG11_HUMAN; Gng11; GNGT11; Guanine nucleotide binding protein G; Guanine nucleotide binding protein gamma 11; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; IG; Osubunit gamma 11 precursor; SG. Research Area Tumour Cell biology Neurobiology Signal transduction G protein-coupled receptor The new supersedes the old G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 8kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GNG11: 31-70/73 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit:
G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Abundantly expressed in all tissues tested except for brain.
Similarity:
Belongs to the G protein gamma family.
SWISS:
P61952
Gene ID:
2791
Database links:Entrez Gene: 2791 Human
Entrez Gene: 66066 Mouse
Omim: 604390 Human
SwissProt: P61952 Human
SwissProt: P61953 Mouse
Unigene: 83381 Human
Unigene: 25547 Mouse
Unigene: 892 Rat
Product Picture Tissue/cell: Rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GNG11 Polyclonal Antibody, Unconjugated(SL13467R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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