Product Name	GGN
Chinese Name	配子生成素抗体
Alias	FLJ35713; Gametogenetin; MGC33369; GGN_HUMAN.
literatures	Specific References  (1)     |     SL13347R has been referenced in 1 publications. [IF=1.935] Liu Z et al. GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer. Pathol Oncol Res. 2019 Feb 5.  WB&IHC-P ;  Human.   PubMed:30721393
Research Area	Cell biology  Developmental biology  Stem cells  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	67kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GGN/Gametogenetin: 5-100/652
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Gametogenetin is a 652 amino acid protein that is primarily expressed in testis and ovary. Interacting with POG (proliferation of germ cells), GGNBP1 and LCRG1, gametogenetin is likely involved in spermatogenesis. Gametogenetin exists as three alternatively spliced isoforms commonly known as gametogenetin protein 1 (GGN1), gametogenetin protein 2 (GGN2) and gametogenetin protein 3 (GGN3), which localize to nuclear membrane, cytoplasm and nucleus/nucleoli, respectively. GGN1 contains two transmembrane domains in its N-terminal half and 2 C-terminal arginine- and lysine-rich nucleolar targeting sequences. GGN1 and GGN3 are likely linked to germ cell development and both GGN1 and GGN2 may be involved in cell trafficking. Function: Gametogenetin gene is a germ cell specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. Subunit: Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2. SWISS: Q86UU5 Gene ID: 199720 Database links: Entrez Gene: 199720 Human Entrez Gene: 243897 Mouse Entrez Gene: 292765 Rat Omim: 609966 Human SwissProt: Q86UU5 Human SwissProt: Q80WJ1 Mouse SwissProt: Q66HC8 Rat
Product Picture	Sample: A549 (human)cell Lysate at 40 ug Primary: Anti- GGN(SL13347R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67kD Observed band size: 67 kD Tissue/cell: rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GGN Polyclonal Antibody, Unconjugated(SL13347R) 1:1000, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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