Product Name	GCC1
Chinese Name	高尔基体卷曲螺旋蛋白1抗体
Alias	GCC protein; GCC1P; GCC88; Golgi coiled coil 1; Golgi coiled coil protein 1; GRIP and coiled coil domain containing 1; Peripheral membrane Golgi protein; GCC1_HUMAN.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	88kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GCC1: 401-500/775
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GCC1 is a 775 amino acid cytoplasmic and peripheral membrane protein of the Golgi apparatus. Involved in maintenance of Golgi structure, GCC1 is essential for retrograde transport of cargo from the early endosomes to the trans-Golgi network. GCC1 contains one GRIP domain and is encoded by a gene that maps to human chromosome 7q32.1. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: GCC1 is a peripheral membrane protein and is sensitive to brefeldin A. GCC1 contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. Subcellular Location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Similarity: Contains 1 GRIP domain. SWISS: Q96CN9 Gene ID: 79571 Database links: Entrez Gene: 79571 Human Omim: 607418 Human SwissProt: Q96CN9 Human Unigene: 521168 Human
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-GCC1 (SL13310R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 88 kD Observed band size: 88 kD Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GCC1) Polyclonal Antibody, Unconjugated (SL13310R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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