Product Name	Syndecan-1
Chinese Name	多配体蛋白聚糖1（CD138）抗体
Alias	SDC1; SDC; SYND1; Syndecan I; SyndecanI; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.
literatures	Specific References  (9)     |     SL1309R has been referenced in 9 publications. [IF=5.763] You Shuang. et al. Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation. REGEN BIOMATER. 2023 Apr;:  IHC ;  Rat.   PubMed:37122820 [IF=5.733] Jiang Yufei. et al. Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation. Hum Reprod. 2020 Nov;35(11):2439-2453  IP ;  Human.   PubMed:33047116 [IF=4.831] Linlin Yanget al. CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis. Aging (Albany NY) . 2020 Jul 13;12(13):13668-13683.  IHC, IF ;  Human.   PubMed:32658867 [IF=3.616] Shugen Xu. et al. Effect of miR-21-3p on lung injury in rats with traumatic hemorrhagic shock resuscitated with sodium bicarbonate Ringer’s solution. ANN TRANSL MED. 2022 Dec; 10(24): 1331  WB ;  Rat.   PubMed:36660723 [IF=2.97] Hambruch, N., et al. "Bovine placentomal heparanase and syndecan expression is related to placental maturation." Placenta.  IHC-P ;  Bovine.   PubMed:28864018 [IF=2.65] Miyatani, Kozo, et al. "A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis." Virchows Archiv (2016): 1-9.  IHC-F ;  Human.   PubMed:26951261 [IF=2.54] Chen, Song, et al. "Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis." Journal of Histochemistry & Cytochemistry (2017): 0022155417692536.  IHC-P ;  Mouse.   PubMed:28170292 [IF=2.273] Haibo Xie. et al. Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury:. TOXICOL IND HEALTH. 2022;38(5):287-298  WB ;  Mouse.   PubMed:35466825 [IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.   PubMed:ISSN:1936-2625/IJCEP0080924
Research Area	Tumour  Neurobiology  The cell membrane受体  Cell adhesion molecule  Cell Surface Molecule  glycoprotein  epithelial cells  endothelial cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Cow,  (predicted: Chicken, Dog, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Detection molecular weight	50 kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD138: 201-310/310 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] Function: Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Subunit: Interacts with CDCP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form. Post-translational modifications: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. Similarity: Belongs to the syndecan proteoglycan family. SWISS: P18827 Gene ID: 6382 Database links: Entrez Gene: 6382 Human Entrez Gene: 20969 Mouse Entrez Gene: 25216 Rat Omim: 186355 Human SwissProt: P18827 Human SwissProt: P18828 Mouse SwissProt: P26260 Rat Unigene: 224607 Human Unigene: 665958 Human Unigene: 2580 Mouse Unigene: 11176 Rat Syndecan1(CD138)属于Syndecans基因家族，该家族是一类细胞表面Transmembrane protein多糖 ,是膜表面粘附受体 ,参与细胞-Extracellular matrix之间的粘附。 CD138表达于epithelial cells、胚胎间质细胞、血管平滑肌细胞、endothelial cells和神经细胞基底膜。Syndecan-1与恶性Tumour的发生发展、浸润及转移有关，着色于胞浆和胞膜.
Product Picture	Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Mouse Liver tissue lysates Lane 3: Human U251 cell lysates Lane 4: Human A431 cell lysates Lane 5: Human HepG2 cell lysates Lane 6: Human HeLa cell lysates Primary: Anti-Syndecan-1 (SL1309R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kDa Observed band size: 74 kDa Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (SL1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (SL1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (SL1309R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Blank control: Hela(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 1μg in 100 μL1X PBS containing 0.5% BSA(green).

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