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Product Name EMSY Chinese Name EMSY蛋白抗体 Alias C11orf30; Chromosome 11 open reading frame 30; EMSY protein; FLJ90741; GL002; Protein EMSY; EMSY_HUMAN. Research Area Tumour Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 141kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human EMSY: 721-820/1322 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail EMSY binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1 and BS69, and localizes to sites of repair following DNA damage. Its levels are amplified in breast and ovarian cancer.
Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
Subunit:
Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5.
Subcellular Location:
Nuclear. Localizes to DNA damage markers in irradiated cells; suggesting that it participates in the DNA repair process.
Similarity:
Contains 1 ENT (EMSY N-terminal) domain.
SWISS:
Q7Z589
Gene ID:
56946
Database links:Entrez Gene: 56946 Human
Entrez Gene: 233545 Mouse
Omim: 608574 Human
SwissProt: Q7Z589 Human
SwissProt: Q8BMB0 Mouse
Unigene: 352588 Human
Unigene: 387819 Mouse
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