Product Name	Phospho-EEF2 (Thr56 + Thr58)
Chinese Name	磷酸化真核翻译延长因子2抗体
Alias	EEF2 (phospho T56 + T58); p-EEF2 (phospho T56 + T58); EEF 2; Eef2; EF-2; EF2; EF2_HUMAN; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase.
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human EEF2 around the phosphorylation site of Thr56+Thr58: RF(p-T)D(p-T)RK
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EEF2 is a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Subunit: Component of the mRNA surveillance SURF complex, at leastcomposed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1,SMG8 and SMG9. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation by EF-2 kinase completely inactivates EF-2. Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis. ISGylated. Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. SWISS: P13639 Gene ID: 1938 Database links: Entrez Gene: 1938 Human SwissProt: P13639 human
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti- Phospho-EEF2 (Thr56 + Thr58) (SL13057R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 95 kD Observed band size: 95 kD

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