Product Name	Plakophilin 3
Chinese Name	桥粒斑菲素蛋白3抗体
Alias	PKP 3 ; PKP3 ; PKP3_HUMAN ; Plakophilin 3b ; Plakophilin-3 ; Plakophilin3.
Research Area	Cell biology  Developmental biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	87kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Plakophilin 3: 631-730/797
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] Function: May play a role in junctional plaques. Subcellular Location: Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes. Tissue Specificity: Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Similarity: Belongs to the beta-catenin family. Contains 8 ARM repeats. SWISS: Q9Y446 Gene ID: 11187 Database links: Entrez Gene: 11187 Human Entrez Gene: 56460 Mouse Entrez Gene: 293619 Rat Omim: 605561 Human SwissProt: Q9Y446 Human SwissProt: Q9QY23 Mouse Unigene: 534395 Human Unigene: 350037 Mouse Unigene: 144803 Rat

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