TEL: +86 571 56623320 EMAIL: [email protected]
Product Name PKIB Chinese Name 蛋白激酶抑制蛋白β抗体 Alias cAMP dependent protein kinase inhibitor 2; cAMP-dependent protein kinase inhibitor beta; FLJ23817; IPKB_HUMAN; OTTHUMP00000017115; OTTHUMP00000017116; OTTHUMP00000017117; PKI-beta; PKIB; PRKACN2; Protein kinase (cAMP dependent, catalytic) inhibitor beta. Research Area Tumour Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 8kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PKIB: 11-60/78 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Subcellular Location:
cytoplasm.
Similarity:
Belongs to the PKI family.
SWISS:
Q9C010
Gene ID:
5570
Database links:Entrez Gene: 5570 Human
Entrez Gene: 18768 Mouse
Omim: 606914 Human
SwissProt: Q9C010 Human
SwissProt: Q04758 Mouse
Unigene: 726217 Human
Unigene: 262135 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PKIB) Polyclonal Antibody, Unconjugated (SL12692R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Scan Wechat Qrcode