Product Name	PKD1L2
Chinese Name	多囊肾蛋白1样蛋白2抗体
Alias	PC1 like 2 protein; PC1-like 2 protein; PK1L2_HUMAN; PKD1L 2; Pkd1l2; Polycystic kidney disease 1 like protein 2; Polycystic kidney disease 1-like protein 2; Polycystic kidney disease protein 1-like 2; Polycystin 1 like 2; Polycystin-1L2.
Research Area	Cell biology  Developmental biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	271kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PKD1L2: 2351-2459/2459 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Function: May function as an ion-channel regulator. May function as a G-protein-coupled receptor. Subunit: May interact via its C-terminus with GNAS and GNAI1. Tissue Specificity: Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney. Similarity: Belongs to the polycystin family. Contains 1 C-type lectin domain. Contains 1 GPS domain. Contains 1 PLAT domain. SWISS: Q7Z442 Gene ID: 114780 Database links: Entrez Gene: 114780 Human Omim: 607894 Human SwissProt: Q7Z442 Human Unigene: 413525 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PKD1L2) Polyclonal Antibody, Unconjugated (SL12691R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PKD1L2) Polyclonal Antibody, Unconjugated (SL12691R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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