Product Name	PDE6D
Chinese Name	磷酸二酯酶6δ抗体
Alias	PDE6 delta; 5''-cyclic phosphodiesterase subunit delta; GMP PDE delta; GMP-PDE delta; p17 protein; PDE 6; PDE 6D; PDE D; PDE6; PDE6D; PDE6D_HUMAN; PDED; Phosphodiesterase 6D cGMP specific; Phosphodiesterase 6D cGMP specific rod delta; Protein p17; Retinal rod photoreceptor cGMP phosphodiesterase delta; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta; Retinal rod rhodopsin-sensitive cGMP 3''.
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Cow, Horse, Rabbit, Zebrafish, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDE6D: 1-100/150
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014] Function: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Tissue Specificity: Retina. Similarity: Belongs to the PDE6D/unc-119 family. SWISS: O43924 Gene ID: 5147 Database links: Entrez Gene: 281976 Cow Entrez Gene: 403781 Dog Entrez Gene: 5147 Human Entrez Gene: 18582 Mouse Entrez Gene: 363272 Rat Omim: 602676 Human SwissProt: Q95142 Cow SwissProt: Q9XT54 Dog SwissProt: O43924 Human SwissProt: O55057 Mouse Unigene: 516808 Human Unigene: 12925 Mouse Unigene: 44816 Rat

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