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Product Name phospho-MYBL2 (Ser577) Chinese Name 磷酸化转录因子MYB相关蛋白B抗体 Alias B MyB (phospho S577); p-B MyB (phospho S577); p-B MyB (phospho S581) (mouse); MYBB_HUMAN; Myb-related protein B; BMYB; B-Myb; B MyB; Myb-like protein 2; Product Type Phosphorylated anti Research Area Tumour Cell biology Signal transduction Cyclin transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Rabbit, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 79kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human MYBL2 around the phosphorylation site of Ser577: RR(p-S)PI Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in the regulation of cell survival, proliferation, and differentiation. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes.
Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Subunit:
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
Similarity:
Contains 3 HTH myb-type DNA-binding domains.
SWISS:
P10244
Gene ID:
4605
Database links:Entrez Gene: 4605 Human
Entrez Gene: 17865 Mouse
Omim: 601415 Human
SwissProt: P10244 Human
SwissProt: P48972 Mouse
Unigene: 179718 Human
Unigene: 4594 Mouse
Unigene: 20824 Rat
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