Product Name	ATPIF1
Chinese Name	ATPIF1蛋白抗体
Alias	ATIF1_HUMAN; ATP synthase inhibitor protein; ATPase inhibitor; ATPase inhibitor mitochondrial; ATPase inhibitor protein; ATPase inhibitory factor 1; ATPI; ATPIF 1; ATPIF1; ATPIP; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase; IP; MGC1167; MGC8898; mitochondrial.
Research Area	Tumour  Cell biology  Signal transduction  The new supersedes the old  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ATPIF1/ATPase Inhibitory Factor 1: 26-106/106
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells. Function: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Subunit: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0 (By similarity). Subcellular Location: Mitochondrion. Post-translational modifications: Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid. Similarity: Belongs to the ATPase inhibitor family. SWISS: Q9UII2 Gene ID: 93974 Database links: Entrez Gene: 93974 Human Entrez Gene: 11983 Mouse Entrez Gene: 25392 Rat Entrez Gene: 327699 Cow SwissProt: P01096 Cow SwissProt: Q9UII2 Human SwissProt: O35143 Mouse SwissProt: Q03344 Rat Unigene: 59150 Cow Unigene: 590908 Human Unigene: 726089 Human Unigene: 2171 Mouse Unigene: 1658 Rat
Product Picture	Sample: Lane 1: Human HeLa cell lysates Lane 2: Human K562 cell lysates Lane 3: Human U937 cell lysates Lane 4: Human 293T cell lysates Primary: Anti-ATPIF1 (SL12550R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 10 kDa Observed band size: 10 kDa

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