Product Name	ATF5
Chinese Name	活化转录因子5抗体
Alias	Activating transcription factor 5 alpha/beta; Activating transcription factor 5; Activating transcription factor X; AFTA; ATF 5; ATF 7; ATF7; ATFX; BZIP protein ATF7; cAMP dependent transcription factor ATF 5; cAMP dependent transcription factor ATF5; Cyclic AMP dependent transcription factor ATF 5; Cyclic AMP dependent transcription factor ATF5; FLJ34666; HMFN0395; MGC102397; NAP1; NRIF3 associated protein; ODA 10; Transcription factor ATFx; Transcription factor like protein ODA 10; Transcription factor like protein ODA10; ATF5_HUMAN.
Research Area	Cell biology  immunology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ATF5: 201-282/282
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB3 and Luman), CREM-1, CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-5 (ATFx), which can localize to the cytoplasm or the nucleus, binds DNA as a dimer. It interacts with CCND3 and PTP4A1. Function: ATF5 or Activating transcription factor 5, binds to cAMP inducible promoters and is involved in gene transcription. This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF5 plays a role in inhibition of nerve growth factor induced neuronal outgrowth and regulation of neurogenesis. Subunit: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34. Subcellular Location: Cytoplasmic and Nuclear Post-translational modifications: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Similarity: Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain. SWISS: Q9Y2D1 Gene ID: 22809 Database links: Entrez Gene: 22809 Human Entrez Gene: 107503 Mouse Entrez Gene: 282840 Rat Omim: 606398 Human SwissProt: Q9Y2D1 Human SwissProt: O70191 Mouse SwissProt: Q6P788 Rat Unigene: 9754 Human Unigene: 389890 Mouse
Product Picture	Sample: NIH/3T3(Mouse) Cell Lysate at 30 ug Primary: Anti-ATF5 (SL12542R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD

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