Product Name	APOA1BP/AI-BP
Chinese Name	载LipoproteinA1Binding protein抗体抗体
Alias	AI BP; AIBP; ApoA I binding protein; Apolipoprotein A I binding protein; MGC119143; MGC119144; MGC119145; YjeF N terminal domain containing protein 1; YJEFN1; NNRE_HUMAN.
Research Area	Cardiovascular  Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Chimpanzee, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human APOA1BP/AI-BP: 201-288/288
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Apolipoproteins are protein components of plasma lipoproteins. Apolipoprotein A-I (ApoA1) promotes cholesterol efflux from tissues to the liver for excretion. ApoA1 is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase, which is responsible for the formation of most plasma cholesteryl esters. AI-BP (Apolipoprotein A-I-binding protein), also known as YjeF N-terminal domain-containing protein 1, is a 288 amino acid secreted protein that binds ApoA1, ApoA2 and HDL. Individuals with impaired renal function show an increased rate of AI-BP excretion, indicating that it is normally reabsorbed within the kidney tubules. AI-BP belongs to the YjeF N-terminal domain protein family, which includes proteins that are frequently involved in oogenesis and spermatogenesis. There are two isoforms of AI-BP that are produced as a result of alternative splicing events. Function: APOA1BP interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. Subunit: Homodimer (By similarity). Interacts with APOA1 and APOA2. Subcellular Location: Secreted Tissue Specificity: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). Post-translational modifications: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation (By similarity). Similarity: Belongs to the nnrE/AIBP family. Contains 1 YjeF N-terminal domain. SWISS: Q8NCW5 Gene ID: 128240 Database links: Entrez Gene: 128240 Human Entrez Gene: 246703 Mouse Entrez Gene: 780405 Pig Entrez Gene: 295229 Rat Omim: 608862 Human SwissProt: Q6QRN6 Cow SwissProt: E2QRY6 Dog SwissProt: Q8NCW5 Human SwissProt: Q8K4Z3 Mouse SwissProt: Q0PIT9 Pig SwissProt: B0BNM1 Rat Unigene: 528320 Human Unigene: 205996 Mouse Unigene: 14886 Rat

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