Product Name	Fibromodulin
Chinese Name	纤维调节蛋白抗体
Alias	Collagen binding 59 kDa protein; Collagen-binding 59 kDa protein; Fibromodulin; Fibromodulin precursor; Fibromodulin proteoglycan; FM; FMOD; FMOD_HUMAN; Keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin; SLRR2E.
literatures	Specific References  (4)     |     SL12362R has been referenced in 4 publications. [IF=7.581] Cherry Christopher. et al. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. GEROSCIENCE. 2023 Apr;:1-29  IF ;  Mouse.   PubMed:37079217 [IF=5.039] Wang Y et al. Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT‐3 signalling pathway. Cell Prolif. 2019 Jun 21:e12650.  IHC-P ;  Rat.   PubMed:31225686 [IF=3.352] Shunshun Han. et al. Fibromodulin is involved in autophagy and apoptosis of granulosa cells affecting the follicular atresia in chicken. Poultry Sci. 2021 Oct;:101524  WB ;  chicken.   PubMed:34784514 [IF=2.36] Simões et al. Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study. (2017) J.Ovarian.Res. 10:54  WB ;  Human.   PubMed:28789706
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Fibromodulin: 121-180/376
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Fibromodulin is a ubiquitous protein that is most prominent in articular cartilage, tendon, and ligament. The human Fibromodulin gene maps to chromosome 1q32 and encodes a 376 amino acid protein. Function: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Subunit: Binds to type I and type II collagen (By similarity). Subcellular Location: Secreted, extracellular space, extracellular matrix. Post-translational modifications: Binds keratan sulfate chains. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. Contains 11 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: Q06828 Gene ID: 2331 Database links: Entrez Gene: 281168 Cow Entrez Gene: 2331 Human Entrez Gene: 14264 Mouse Entrez Gene: 64507 Rat Omim: 600245 Human SwissProt: P13605 Cow SwissProt: Q06828 Human SwissProt: P50608 Mouse SwissProt: P50609 Rat Unigene: 519168 Human Unigene: 287146 Mouse Unigene: 8778 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Fibromodulin) Polyclonal Antibody, Unconjugated (SL12362R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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