Product Name	ASPSCR1
Chinese Name	腺泡状软组织肉瘤结构域蛋白ASPC抗体
Alias	Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma chromosome region candidate 1 (human); Alveolar soft part sarcoma locus; ASPC; ASPC1_HUMAN; ASPCR 1; ASPCR1; ASPL; ASPS; ASPSCR 1; FLJ45380; RCC 17; RCC17; renal cell carcinoma gene on chromosome 17; renal cell carcinoma papillary 17; Renal papillary cell carcinoma protein 17; Tether containing a UBX domain for GLUT4; Tether containing UBX domain for GLUT4; TUG; UBX domain containing protein 9; UBX domain protein 9; UBX domain-containing protein 9; UBXD 9; UBXD9; UBXN 9; UBXN9.
Research Area	Tumour  Cell biology  Signal transduction  Growth factors and hormones  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TUG/ASPC: 351-420/553
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glut4 is a twelve pass transmembrane protein (12TM) whose carboxy-terminus may dictate its cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity. TUG (ASPL in humans) regulates the trafficking of glucose via Glut4. Full-length TUG forms a complex with Glut4 and in 3T3-L1 adipocytes and this complex is present in unstimulated cells and is disassembled by insulin. TUG acts by trapping endocytosed Glut4 and tethering it intracellularly. Insulin mobilizes this pool of retained Glut4 by releasing the tether. Function: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Subunit: Interacts with GLUT4. Subcellular Location: Endomembrane system; Peripheral membrane protein. Tissue Specificity: Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. DISEASE: Note=A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein. Note=A chromosomal aberration involving ASPSCR1 has been found in two patients with of papillary renal cell carcinoma. Translocation t(X;17)(p11.2;q25). Similarity: Contains 1 UBX domain. SWISS: Q9BZE9 Gene ID: 79058 Database links: Entrez Gene: 79058 Human Entrez Gene: 68938 Mouse Entrez Gene: 691026 Rat Omim: 606236 Human SwissProt: Q9BZE9 Human SwissProt: Q8VBT9 Mouse Unigene: 298351 Human Unigene: 294020 Mouse Unigene: 20298 Rat
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-TUG  (SL12355R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 58 kD Paraformaldehyde-fixed, paraffin embedded (human colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ASPSCR1) Polyclonal Antibody, Unconjugated (SL12355R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat colon tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TUG) Polyclonal Antibody, Unconjugated (SL12355R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TUG) Polyclonal Antibody, Unconjugated (SL12355R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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