Product Name	GSC
Chinese Name	同源盒蛋白GSC抗体
Alias	Goosecoid; goosecoid homeobox; GSC; GSC2; GSC_HUMAN; homeobox protein goosecoid-like; homeobox protein goosecoid-2; Homeobox protein goosecoid; GSC 2; GSCL; Homeobox protein goosecoid 2; Homeobox protein goosecoid like.
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Rabbit, Zebrafish, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	28kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human GSC: 151-257/257
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Goosecoid is a homeodomain transcription factor with DNA binding specificity identical to that of the anterior morphogen 'bicoid' in Drosophila.During mouse embryogenesis, GSC influences development of the lower mandible and its associated musculature, including the tongue, the nasal cavity, and the nasal pits, as well as components of the inner ear and the external auditory meatus. The GSC gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. Function: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Subcellular Location: Nucleus. Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. SWISS: O15499 Gene ID: 2928 Database links: Entrez Gene: 2928 Human Entrez Gene: 195333 Mouse SwissProt: O15499 Human SwissProt: P56916 Mouse
Product Picture	Tissue/cell: Rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GSC Polyclonal Antibody, Unconjugated(SL12352R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: Rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GSC Polyclonal Antibody, Unconjugated(SL12352R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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