Product Name	HHIP
Chinese Name	HHIP蛋白抗体
Alias	FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; HIP.
Research Area	Cell biology  Developmental biology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	77kDa
Cellular localization	cytoplasmic The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HHIP: 501-600/700
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling. Function: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Subunit: Interacts with all three hedgehog family members, SHH, IHH and DHH. Subcellular Location: Cytoplasm and Cell membrane. Secreted. The last 22 C-terminal amino acids may participate in cell membrane attachment. Tissue Specificity: Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. Similarity: Belongs to the HHIP family. Contains 2 EGF-like domains. SWISS: Q96QV1 Gene ID: 64399 Database links: Entrez Gene: 540830 Cow Entrez Gene: 64399 Human Entrez Gene: 15245 Mouse Omim: 606178 Human SwissProt: Q96QV1 Human SwissProt: Q7TN16 Mouse Unigene: 507991 Human Unigene: 254493 Mouse

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