Product Name	HHATL
Chinese Name	甘油吸收/TransporterGUP1抗体
Alias	C3orf3; Glycerol uptake/transporter homolog; GUP1; GUP1 glycerol uptake/transporter homolog; Hedgehog acyltransferase like; Hedgehog acyltransferase-like protein; Hhatl; HHATL_HUMAN; KIAA1173; MBOAT3; Membrane bound O acyltransferase domain containing 3; MSTP002; OACT3; Protein-cysteine N-palmitoyltransferase HHAT-like protein.
Research Area	Cell biology  Developmental biology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human HHATL/GUP1: 25-125/504
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential. Function: Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Subunit: Interacts with SHH (By similarity). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Heart-specific. Similarity: Belongs to the membrane-bound acyltransferase family. HHAT subfamily. SWISS: Q9HCP6 Gene ID: 57467 Database links: Entrez Gene: 57467 Human Entrez Gene: 74770 Mouse Entrez Gene: 301073 Rat Omim: 608116 Human SwissProt: Q9HCP6 Human SwissProt: Q9D1G3 Mouse Unigene: 476041 Human

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