Product Name	CEP135
Chinese Name	中心体蛋白135抗体
Alias	centrosomal protein 135 kDa; centrosomal protein 135kDa; Centrosomal protein 4; Centrosomal protein of 135 kDa; centrosome protein 4; centrosome protein cep135; Cep135; Cep135; CEP4; CP135_HUMAN.
Research Area	Cell biology  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	133kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CEP135: 1001-1100/1140
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Function: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Subunit: Interacts with DCTN2 (By similarity). Interacts with CEP250. Subcellular Location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. DISEASE: Defects in CEP135 are the cause of microcephaly, primary, type 8 (MCPH8) [MIM:614673]. MCPH8 is a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Similarity: Belongs to the CEP135/TSGA10 family. SWISS: Q66GS9 Gene ID: 9662 Database links: Entrez Gene: 9662 Human Entrez Gene: 381644 Mouse Omim: 611423 Human SwissProt: Q66GS9 Human SwissProt: Q6P5D4 Mouse Unigene: 518767 Human Unigene: 332452 Mouse
Product Picture	Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti-CEP135 (SL12282R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 133 kD Observed band size: 133 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-CEP135 (SL10196R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 133 kD Observed band size: 133 kD

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