Product Name	NANOS1
Chinese Name	生殖细胞增殖相关蛋白NANOS1抗体
Alias	EC Rep1a; EC_Rep1a; NANO1_HUMAN; NANOS 1; Nanos homolog 1 (Drosophila); Nanos homolog 1; NANOS1; Nos 1; NOS-1; Nos1; OTTHUMP00000046853; Rep 1a; Rep1a; Nanos Homologue 1.
Research Area	Tumour  Developmental biology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human NANOS1: 221-330/292
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Nanos1is a 292 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one nanos-type zinc finger. Expressed at high levels in spermatogonia and present at lower levels in fetal ovaries, Nanos1 forms a complex with Pumilio 2 and functions to regulate the translation of select mRNAs, specifically via association with the 3’-UTR of its mRNA targets. Additionally, Nanos1 is required for the establishment and maintenance of germline stem cells, as it prevents their premature entry into oogenesis. The gene encoding Nanos1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Subunit: Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Subcellular Location: Cytoplasm. Tissue Specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. DISEASE: Fetal ovary and fetal testis (at protein level). Similarity: Belongs to the nanos family. Contains 1 nanos-type zinc finger. SWISS: Q8WY41 Gene ID: 340719 Database links: Entrez Gene: 340719 Human Omim: 608226 Human SwissProt: Q8WY41 Human Unigene: 591918 Human
Product Picture	Sample: A431(Human) Cell Lysate at 30 ug Primary: Anti- NANOS1 (SL12272R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 33 kD

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