Product Name	phospho-CXCR2 (Ser347)
Chinese Name	磷酸化细胞表面Chemokine受体2抗体
Alias	CXCR2 (phospho S347); CXCR2 (phospho Ser347); p-CXCR2 (phospho S347); p-CD182 (phospho Ser347); CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine (CXC) receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2; CXCR2_HUMAN; C-X-C chemokine receptor type 2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2.
literatures	Specific References  (1)     |     SL12257R has been referenced in 1 publications. [IF=3.098] Rui Zou. et al. Role of integrin‑linked kinase in static compressive stress‑induced autophagy via phosphatidylinositol 3 kinase in human periodontal ligament cells. Int J Mol Med. 2021 Sep;48(3):1-11  WB ;  Human.   PubMed:34278436
Product Type	Phosphorylated anti
Research Area	Cell biology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Dog, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser347: RP(p-S)FV
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylated upon ligand binding; which is required for desensitization. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25025 Gene ID: 3579 Database links: Entrez Gene: 3579 Human Entrez Gene: 12765 Mouse Entrez Gene: 29385 Rat Omim: 146928 Human SwissProt: P25025 Human SwissProt: P35343 Mouse SwissProt: P35407 Rat
Product Picture	Sample: Bone (Mouse) Lysate at 40 ug Primary: Anti-phospho-CXCR2 (Ser347) (SL12257R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 51 kD Sample: Lane 1: HL60 (Human) Cell Lysate at 30 ug Lane 2: Skin (Mouse) Lysate at 40 ug Primary: Anti-phospho-CXCR2 (Ser347) (SL12257R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45/55 kD Observed band size: 48 kD

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Totalgoods,subtotals:￥Checkout