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Product Name SNX7 Chinese Name 分选连接蛋白7抗体 Alias MGC8717; DKFZP564F052; MGC8717; MGC8717; ; Sorting nexin 7; Sorting nexin 7 isoform a; SNX7_HUMAN. Research Area Cell biology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 45kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Human SNX7: 151-250/387 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX7 is unique in that it does not have a coiled coil region like some of the SNX family members. Mutations in the SNX7 gene have not been shown to cause any diseases.
Function:
SNX7 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its function is unknown. Its gene results in two transcript variants encoding two distinct isoforms.
Subcellular Location:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
Similarity:
Belongs to the sorting nexin family.
Contains 1 PX (phox homology) domain.
SWISS:
Q9UNH6
Gene ID:
51375
Database links:Entrez Gene: 51375 Human
Entrez Gene: 76561 Mouse
Omim: 614904 Human
SwissProt: Q9UNH6 Human
SwissProt: Q9CY18 Mouse
Unigene: 197015 Human
Unigene: 33824 Mouse
Unigene: 29845 Rat
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