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Rabbit Anti-Kv2.2 antibody
Rabbit Anti-Kv2.2 antibody
delayed rectifier potassium channel protein; KCNB2; KCNB2_HUMAN; potassium channel Kv2.2; potassium voltage gated channel subfamily B member 2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2.
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  • NO.:SL12186R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep,)
    Applications:WB ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name Kv2.2
Chinese Name 电压门控性钾通道Kv2.2抗体
Alias delayed rectifier potassium channel protein; KCNB2; KCNB2_HUMAN; potassium channel Kv2.2; potassium voltage gated channel subfamily B member 2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2.  
Research Area Cell biology  immunology  Neurobiology  Channel protein  The cell membrane受体  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 102kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human Kv2.2: 21-120/911 <Cytoplasmic>
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3, KV4 and KV9 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV2.2 is a multi-pass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. Its tail may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.

Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

Subunit:
Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Post-translational modifications:
Phosphorylated.

Similarity:
Belongs to the potassium channel family.
B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.

SWISS:
Q92953

Gene ID:
9312

Database links:
Entrez Gene: 9312 Human

Entrez Gene: 98741 Mouse

Entrez Gene: 117105 Rat

Omim: 607738 Human

SwissProt: Q92953 Human

SwissProt: A6H8H5 Mouse

SwissProt: Q63099 Rat

Unigene: 661102 Human

Unigene: 6702 Human

Unigene: 156081 Mouse

Unigene: 382301 Mouse

Unigene: 32101 Rat

 



Product Picture
Sample:
Stomach (Mouse) Lysate at 40 ug
Primary: Anti-Kv2.2 (SL12186R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 102 kD
Observed band size: 102 kD

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